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Galectin Therapeutics galectin 3 inhibitor gb1107 administration
Galectin 3 Inhibitor Gb1107 Administration, supplied by Galectin Therapeutics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/galectin-3+inhibitor/gb1107/pm42298444-98-11-11
Average 86 stars, based on 1 article reviews
galectin 3 inhibitor gb1107 administration - by Bioz Stars, 2026-09
86/100 stars

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Related Articles

Drug discovery:

Article Title: Raman spectroscopic modality to examine therapeutic efficacy of Galectin-3 inhibitor in prostate cancer.
Article Snippet: Glycoproteins, such as Galectin-3 (Gal-3) and Prostate Specific Membrane Antigen (PSMA), are functional proteins involved in numerous biological activities that include cell apoptosis, angiogenesis, and inflammation.. Downregulation of both in the highly metastatic human Prostate Cancer (CaP) cell line PC-3 reduces tumor growth.. We used Raman Spectroscopy (RS) to examine the effect of a potent Gal-3 inhibitor (GB1107) in CaP cell lines of varying metastatic potential, namely PC-3, DU-145 and LNCaP.

Article Title: EXPRESS: Preoperative reactive oxygen species exacerbate postoperative hyperalgesia by aggravating neuroinflammation through galectin-3.
Article Snippet: Galectin-3 inhibitor alleviated postoperative neuroinflammation in the preoperative ROS-increased model To explore the mechanism of galectin-3-induced hyperalgesia, we administered GB1107 intrathecally for 5 consecutive days following t-BOOH injection and plantar incision.

Article Title: Characterisation of an autochthonous mouse ccRCC model of immune checkpoint inhibitor therapy resistance
Article Snippet: Specific inhibitors of GALECTIN-3 have also been developed and these may represent an attractive alternative therapeutic strategy to block LAG-3 signalling as well as other potentially pro-tumourigenic biological functions of GALECTIN-3 such as promoting angiogenesis, tumour cell intra- and extravasation and metastasis .

Article Title: The silent predictors: exploring galectin-3 and Irisin's tale in severe COVID-19.
Article Snippet: Gaughan EE, Quinn TM, Mills A, Bruce AM, Antonelli J, MacKinnon AC, Aslanis V, Li F, O’Connor R, Boz C, Mills R, Emanuel P, Burgess M, Rinaldi G, Valanciute A, Mills B, Scholefield E, Hardisty G, Findlay EG, Parker RA, Norrie J, Dear JW, Akram AR, Koch O, Templeton K, Dockrell DH, Walsh TS, Partridge S, Humphries D, Wang-Jairaj J, Slack RJ, Schambye H, Phung D, Gravelle L, Lindmark B, Shankar-Hari M, Hirani N, Sethi T, Dhaliwal K. An inhaled Galectin-3 inhibitor in COVID-19 pneumonitis: a phase Ib/IIa Randomized Controlled Clinical Trial (DEFINE).

Article Title: Benzothia(di)azepine compounds and their use as bile acid modulators
Article Snippet: In another embodiment, compounds of formula (I), or pharmaceutically acceptable salts thereof, are administered in combination with a galectin-3 inhibitor, such as GR-MD-02.

Article Title: Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis.
Article Snippet: Galectin-3 inhibitor is now under clinical trial for treating MASH ( 66 ).

Article Title: Epithelial Cell Dysfunction in Pulmonary Fibrosis: Mechanisms, Interactions, and Emerging Therapeutic Targets.
Article Snippet: The research on these inhibitors highlights the potential of targeting Galectin-3 as a therapeutic approach for fibrosis-related diseases.

Clinical Proteomics:

Article Title: Raman spectroscopic modality to examine therapeutic efficacy of Galectin-3 inhibitor in prostate cancer.
Article Snippet: Glycoproteins, such as Galectin-3 (Gal-3) and Prostate Specific Membrane Antigen (PSMA), are functional proteins involved in numerous biological activities that include cell apoptosis, angiogenesis, and inflammation.. Downregulation of both in the highly metastatic human Prostate Cancer (CaP) cell line PC-3 reduces tumor growth.. We used Raman Spectroscopy (RS) to examine the effect of a potent Gal-3 inhibitor (GB1107) in CaP cell lines of varying metastatic potential, namely PC-3, DU-145 and LNCaP.

Article Title: EXPRESS: Preoperative reactive oxygen species exacerbate postoperative hyperalgesia by aggravating neuroinflammation through galectin-3.
Article Snippet: Galectin-3 inhibitor alleviated postoperative neuroinflammation in the preoperative ROS-increased model To explore the mechanism of galectin-3-induced hyperalgesia, we administered GB1107 intrathecally for 5 consecutive days following t-BOOH injection and plantar incision.

Article Title: Characterisation of an autochthonous mouse ccRCC model of immune checkpoint inhibitor therapy resistance
Article Snippet: Specific inhibitors of GALECTIN-3 have also been developed and these may represent an attractive alternative therapeutic strategy to block LAG-3 signalling as well as other potentially pro-tumourigenic biological functions of GALECTIN-3 such as promoting angiogenesis, tumour cell intra- and extravasation and metastasis .

Article Title: The silent predictors: exploring galectin-3 and Irisin's tale in severe COVID-19.
Article Snippet: Gaughan EE, Quinn TM, Mills A, Bruce AM, Antonelli J, MacKinnon AC, Aslanis V, Li F, O’Connor R, Boz C, Mills R, Emanuel P, Burgess M, Rinaldi G, Valanciute A, Mills B, Scholefield E, Hardisty G, Findlay EG, Parker RA, Norrie J, Dear JW, Akram AR, Koch O, Templeton K, Dockrell DH, Walsh TS, Partridge S, Humphries D, Wang-Jairaj J, Slack RJ, Schambye H, Phung D, Gravelle L, Lindmark B, Shankar-Hari M, Hirani N, Sethi T, Dhaliwal K. An inhaled Galectin-3 inhibitor in COVID-19 pneumonitis: a phase Ib/IIa Randomized Controlled Clinical Trial (DEFINE).

Article Title: Benzothia(di)azepine compounds and their use as bile acid modulators
Article Snippet: In another embodiment, compounds of formula (I), or pharmaceutically acceptable salts thereof, are administered in combination with a galectin-3 inhibitor, such as GR-MD-02.

Article Title: Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis.
Article Snippet: Galectin-3 inhibitor is now under clinical trial for treating MASH ( 66 ).

Article Title: Epithelial Cell Dysfunction in Pulmonary Fibrosis: Mechanisms, Interactions, and Emerging Therapeutic Targets.
Article Snippet: The research on these inhibitors highlights the potential of targeting Galectin-3 as a therapeutic approach for fibrosis-related diseases.

Membrane:

Article Title: Raman spectroscopic modality to examine therapeutic efficacy of Galectin-3 inhibitor in prostate cancer.
Article Snippet: Glycoproteins, such as Galectin-3 (Gal-3) and Prostate Specific Membrane Antigen (PSMA), are functional proteins involved in numerous biological activities that include cell apoptosis, angiogenesis, and inflammation.. Downregulation of both in the highly metastatic human Prostate Cancer (CaP) cell line PC-3 reduces tumor growth.. We used Raman Spectroscopy (RS) to examine the effect of a potent Gal-3 inhibitor (GB1107) in CaP cell lines of varying metastatic potential, namely PC-3, DU-145 and LNCaP.

Article Title: EXPRESS: Preoperative reactive oxygen species exacerbate postoperative hyperalgesia by aggravating neuroinflammation through galectin-3.
Article Snippet: Galectin-3 inhibitor alleviated postoperative neuroinflammation in the preoperative ROS-increased model To explore the mechanism of galectin-3-induced hyperalgesia, we administered GB1107 intrathecally for 5 consecutive days following t-BOOH injection and plantar incision.

Article Title: Characterisation of an autochthonous mouse ccRCC model of immune checkpoint inhibitor therapy resistance
Article Snippet: Specific inhibitors of GALECTIN-3 have also been developed and these may represent an attractive alternative therapeutic strategy to block LAG-3 signalling as well as other potentially pro-tumourigenic biological functions of GALECTIN-3 such as promoting angiogenesis, tumour cell intra- and extravasation and metastasis .

Article Title: The silent predictors: exploring galectin-3 and Irisin's tale in severe COVID-19.
Article Snippet: Gaughan EE, Quinn TM, Mills A, Bruce AM, Antonelli J, MacKinnon AC, Aslanis V, Li F, O’Connor R, Boz C, Mills R, Emanuel P, Burgess M, Rinaldi G, Valanciute A, Mills B, Scholefield E, Hardisty G, Findlay EG, Parker RA, Norrie J, Dear JW, Akram AR, Koch O, Templeton K, Dockrell DH, Walsh TS, Partridge S, Humphries D, Wang-Jairaj J, Slack RJ, Schambye H, Phung D, Gravelle L, Lindmark B, Shankar-Hari M, Hirani N, Sethi T, Dhaliwal K. An inhaled Galectin-3 inhibitor in COVID-19 pneumonitis: a phase Ib/IIa Randomized Controlled Clinical Trial (DEFINE).

Article Title: Benzothia(di)azepine compounds and their use as bile acid modulators
Article Snippet: In another embodiment, compounds of formula (I), or pharmaceutically acceptable salts thereof, are administered in combination with a galectin-3 inhibitor, such as GR-MD-02.

Article Title: Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis.
Article Snippet: Galectin-3 inhibitor is now under clinical trial for treating MASH ( 66 ).

Article Title: Epithelial Cell Dysfunction in Pulmonary Fibrosis: Mechanisms, Interactions, and Emerging Therapeutic Targets.
Article Snippet: The research on these inhibitors highlights the potential of targeting Galectin-3 as a therapeutic approach for fibrosis-related diseases.

Raman Spectroscopy:

Article Title: Raman spectroscopic modality to examine therapeutic efficacy of Galectin-3 inhibitor in prostate cancer.
Article Snippet: Glycoproteins, such as Galectin-3 (Gal-3) and Prostate Specific Membrane Antigen (PSMA), are functional proteins involved in numerous biological activities that include cell apoptosis, angiogenesis, and inflammation.. Downregulation of both in the highly metastatic human Prostate Cancer (CaP) cell line PC-3 reduces tumor growth.. We used Raman Spectroscopy (RS) to examine the effect of a potent Gal-3 inhibitor (GB1107) in CaP cell lines of varying metastatic potential, namely PC-3, DU-145 and LNCaP.

Article Title: EXPRESS: Preoperative reactive oxygen species exacerbate postoperative hyperalgesia by aggravating neuroinflammation through galectin-3.
Article Snippet: Galectin-3 inhibitor alleviated postoperative neuroinflammation in the preoperative ROS-increased model To explore the mechanism of galectin-3-induced hyperalgesia, we administered GB1107 intrathecally for 5 consecutive days following t-BOOH injection and plantar incision.

Article Title: Characterisation of an autochthonous mouse ccRCC model of immune checkpoint inhibitor therapy resistance
Article Snippet: Specific inhibitors of GALECTIN-3 have also been developed and these may represent an attractive alternative therapeutic strategy to block LAG-3 signalling as well as other potentially pro-tumourigenic biological functions of GALECTIN-3 such as promoting angiogenesis, tumour cell intra- and extravasation and metastasis .

Article Title: The silent predictors: exploring galectin-3 and Irisin's tale in severe COVID-19.
Article Snippet: Gaughan EE, Quinn TM, Mills A, Bruce AM, Antonelli J, MacKinnon AC, Aslanis V, Li F, O’Connor R, Boz C, Mills R, Emanuel P, Burgess M, Rinaldi G, Valanciute A, Mills B, Scholefield E, Hardisty G, Findlay EG, Parker RA, Norrie J, Dear JW, Akram AR, Koch O, Templeton K, Dockrell DH, Walsh TS, Partridge S, Humphries D, Wang-Jairaj J, Slack RJ, Schambye H, Phung D, Gravelle L, Lindmark B, Shankar-Hari M, Hirani N, Sethi T, Dhaliwal K. An inhaled Galectin-3 inhibitor in COVID-19 pneumonitis: a phase Ib/IIa Randomized Controlled Clinical Trial (DEFINE).

Article Title: Benzothia(di)azepine compounds and their use as bile acid modulators
Article Snippet: In another embodiment, compounds of formula (I), or pharmaceutically acceptable salts thereof, are administered in combination with a galectin-3 inhibitor, such as GR-MD-02.

Article Title: Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis.
Article Snippet: Galectin-3 inhibitor is now under clinical trial for treating MASH ( 66 ).

Article Title: Epithelial Cell Dysfunction in Pulmonary Fibrosis: Mechanisms, Interactions, and Emerging Therapeutic Targets.
Article Snippet: The research on these inhibitors highlights the potential of targeting Galectin-3 as a therapeutic approach for fibrosis-related diseases.

Functional Assay:

Article Title: Raman spectroscopic modality to examine therapeutic efficacy of Galectin-3 inhibitor in prostate cancer.
Article Snippet: Glycoproteins, such as Galectin-3 (Gal-3) and Prostate Specific Membrane Antigen (PSMA), are functional proteins involved in numerous biological activities that include cell apoptosis, angiogenesis, and inflammation.. Downregulation of both in the highly metastatic human Prostate Cancer (CaP) cell line PC-3 reduces tumor growth.. We used Raman Spectroscopy (RS) to examine the effect of a potent Gal-3 inhibitor (GB1107) in CaP cell lines of varying metastatic potential, namely PC-3, DU-145 and LNCaP.

Article Title: EXPRESS: Preoperative reactive oxygen species exacerbate postoperative hyperalgesia by aggravating neuroinflammation through galectin-3.
Article Snippet: Galectin-3 inhibitor alleviated postoperative neuroinflammation in the preoperative ROS-increased model To explore the mechanism of galectin-3-induced hyperalgesia, we administered GB1107 intrathecally for 5 consecutive days following t-BOOH injection and plantar incision.

Article Title: Characterisation of an autochthonous mouse ccRCC model of immune checkpoint inhibitor therapy resistance
Article Snippet: Specific inhibitors of GALECTIN-3 have also been developed and these may represent an attractive alternative therapeutic strategy to block LAG-3 signalling as well as other potentially pro-tumourigenic biological functions of GALECTIN-3 such as promoting angiogenesis, tumour cell intra- and extravasation and metastasis .

Article Title: The silent predictors: exploring galectin-3 and Irisin's tale in severe COVID-19.
Article Snippet: Gaughan EE, Quinn TM, Mills A, Bruce AM, Antonelli J, MacKinnon AC, Aslanis V, Li F, O’Connor R, Boz C, Mills R, Emanuel P, Burgess M, Rinaldi G, Valanciute A, Mills B, Scholefield E, Hardisty G, Findlay EG, Parker RA, Norrie J, Dear JW, Akram AR, Koch O, Templeton K, Dockrell DH, Walsh TS, Partridge S, Humphries D, Wang-Jairaj J, Slack RJ, Schambye H, Phung D, Gravelle L, Lindmark B, Shankar-Hari M, Hirani N, Sethi T, Dhaliwal K. An inhaled Galectin-3 inhibitor in COVID-19 pneumonitis: a phase Ib/IIa Randomized Controlled Clinical Trial (DEFINE).

Article Title: Benzothia(di)azepine compounds and their use as bile acid modulators
Article Snippet: In another embodiment, compounds of formula (I), or pharmaceutically acceptable salts thereof, are administered in combination with a galectin-3 inhibitor, such as GR-MD-02.

Article Title: Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis.
Article Snippet: Galectin-3 inhibitor is now under clinical trial for treating MASH ( 66 ).

Article Title: Epithelial Cell Dysfunction in Pulmonary Fibrosis: Mechanisms, Interactions, and Emerging Therapeutic Targets.
Article Snippet: The research on these inhibitors highlights the potential of targeting Galectin-3 as a therapeutic approach for fibrosis-related diseases.



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Image Search Results


Compartment-specific functions of Galectin-3 and therapeutic targeting strategies in prostate cancer.

Journal: Current Oncology

Article Title: Prostate Cancer Biomarkers with a Focus on Galectin-3: Emerging Clinical and Therapeutic Implications

doi: 10.3390/curroncol33050280

Figure Lengend Snippet: Compartment-specific functions of Galectin-3 and therapeutic targeting strategies in prostate cancer.

Article Snippet: Melanoma & HNSCC , Immune Escape: Gal-3 acts as a negative immune checkpoint, blocking anti-PD-1 antibody binding to T-cells. , Belapectin + Pembrolizumab , Small molecule Galectin-3 inhibitor , Phase I study showed objective response rates of 50% (melanoma) and 33% (HNSCC). Demonstrates that Gal-3 inhibitors may enhance immunotherapy by reversing immune suppression [ , ]. .

Techniques:

Compartment-specific functions of Galectin-3 and therapeutic targeting strategies in prostate cancer.

Journal: Current Oncology

Article Title: Prostate Cancer Biomarkers with a Focus on Galectin-3: Emerging Clinical and Therapeutic Implications

doi: 10.3390/curroncol33050280

Figure Lengend Snippet: Compartment-specific functions of Galectin-3 and therapeutic targeting strategies in prostate cancer.

Article Snippet: Lung & Pancreatic Cancer , KRAS Addiction: Gal-3 supports pro-survival pathways in KRAS-driven tumors. , GB1107 , Novel small molecule Galectin-3 inhibitor , Identified as a druggable vulnerability in hard-to-treat tumors, showing Gal-3 as a key mediator of oncogenic signaling beyond the AR pathway [ ]. .

Techniques: